Tourettes Syndrome
Discover effective treatment options for Tourette's Syndrome with this detailed guide. Learn about medications such as Clonidine and Guanfacine for mild tics, and Pimozide for moderate/severe tics, including considerations for Tourette's syndrome with ADHD.
2023-12-23 02:22:15 - Editor
TOURETTES SYNDROME
Mild tics:
Clonidine
0.05 mg per day starting dose in children , increase gradually to 0.3 mg per day in three divided doses
May need to wait upto 3 months to see an effect
Adults 0.1 mg po bid
May use 0.1mg per day weekly transdermal patches
Hold if BP <90/60
Guanfacine
Start at 1mg at bedtime
After a month, may increase to 2 mg at bedtime.
Hold if BP <90/60
Moderate / severe tics
Pimozide
Pimozide start at 0.5 mg every other day.
Then gradually increase to 0.5-1 mg daily. May increased weekly to 1-4 mg per day if needed.
Pimozide is suitable if Tourette + ADHD, it improves cognition also.
Keep an eye on the QT interval
QT < 440 is normal
Prolonged QT poses risk of TdP