Vascular Dementia
This article offers an in-depth analysis of vascular dementia, characterized as dementia primarily caused by cerebrovascular disease or impaired cerebral blood flow. It covers the causes, risk factors, cognitive profile, and management strategies for vascular dementia, including both non-pharmacological and pharmacological treatments. The article also discusses investigational agents with inconclusive results and is supported by references from various neurological and medical studies.
2023-12-31 17:24:16 - Editor
Defining Vascular Dementia
Vascular dementia is defined as any dementia which is primarily caused by cerebrovascular disease or impaired cerebral blood flow and leads to cognitive impairment. So, vascular dementia encompasses both dementia and milder forms of cognitive impairment.
Causative Factors of Vascular Dementia
Vascular dementia is caused by any cerebrovascular or cardiovascular disease including any of the causes of ischemic stroke or hemorrhagic stroke.
Risk Factors for Vascular Dementia
Risk factors for vascular dementia include pre-stroke risk factors, stroke-factors including intracerebral hemorrhage, aphasia, left hemisphere location and recurrent strokes, post-stroke factors.
Cognitive Profile of Vascular Dementia
The cognitive profile of vascular dementia is marked by prominent impairment of executive functions with relative sparing of episodic memory. It may be accompanied by other cortical signs of stroke including apraxia and aphasia.
Management Strategies for Vascular Dementia
For management; management of risk factor is important. These measures may be helpful to avoid recurrent stroke which is associated with a greater risk of cognitive decline and a higher mortality. These measures include antihypertensive therapy, diabetes control, statins, and antiplatelet therapy.
Non-pharmacological Therapy
Non-pharmacological therapy includes lifestyle interventions, such as, exercise and social interactions, post-stroke programs for cognitive and physical rehabilitation and behavioral therapy for neuropsychiatric symptoms.
Pharmacological Treatments
Pharmacological treatment with cholinesterase inhibitors including donepezil, galantamine-extended release, or rivastigmine. Also, memantine could be added in patients with severe dementia.
Investigational Agents in Vascular Dementia
Additionally, investigational agents include nimodipine, pentoxifylline, actovegin have been studied with inconclusive results.
References
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